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. 2011 Oct 7;286(52):44512–44520. doi: 10.1074/jbc.M111.307587

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© 2011 by The American Society for Biochemistry and Molecular Biology, Inc.

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FIGURE 4. — Poly(Q) aggregation inhibition via Pgl-135 or MW7 expression suppresses mutant httEx1-induced ROS. A, change in DCF or DHE oxidation in HeLa cells expressing httEx1Q97mRFP (DCF) or httEx1Q97EGFP (DHE) compared with httEx1Q25mRFP/EGFP with/without Pgl-135 (50 μm) treatment or co-expression of the intrabody MW7. n = 4 independent experiments, means ± S.E. (error bars). B, change in DHE oxidation in httEx1Q72EGFP ponasterone A cells induced for 6 h with/without Pgl-135 (50 μm) treatment, n = 3 independent experiments, means ± S.D. Student's t test (unpaired), *, p < 0.05; **, p < 0.01.