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. 2011 Oct 7;286(52):44512–44520. doi: 10.1074/jbc.M111.307587

FIGURE 5.

FIGURE 5.

Pgl-135 reduces httEx1Q53 oligomer size and fibril formation. A, aggregation of httEx1Q53 versus httEx1Q20 analyzed by AFM. Poly(Q) fibrils are visible at 5 h. B, representative AFM images of httEx1Q53 aggregation (24 h) in the presence/absence (untreated) of Pgl-135 (50 μm). C, number of fibrillar structures/10-μm AFM scan of httEx1Q53 aggregation as in B, n = 3 independent experiments, means ± S.D. (error bars). D, httEx1Q53 oligomer size (AFM height measurements), n = 3 independent experiments, means ± S.D. E, dot blot showing that Pgl-135 (50 μm) and MW7 antibody reduce httEx1Q53 aggregation (for details, see “Experimental Procedures”). Note that MW7 24 h time point was not done.