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Inhibition of PfFT1 and PfFT2 dependent [3H]folinic acid uptake in Xenopus by methotrexate and the organic anion inhibitor probenecid. Both methotrexate (MTX) and PBN at 200 μm significantly inhibited folinic acid uptake (dark rectangles) via PfFT1 and PfFT2. Significance values between groups of injected oocytes was calculated with non-parametric Mann-Whitney U test using data for at least three different experiments (n = 3).
