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Folding pathways for the thrombin aptamer, 5′-G2T2G2TGTG2T2G2-3′. The numbers indicate steps in the most common pathway (1 → 2 → 3 → 4) and a secondary pathway (1 → 2’ → 3′ → 4). The wire-frame diagram shows a cartoon of the bead positions at the final snapshot time; the dark (purple) bead denotes the 5′ end of the DNA molecule.
