Table 2.
Association results for SNPs in nicotine metabolizing genes with Nicotine Dependence. COGEND sample (N=1610) and ACS sample (N=2844). UGT2 A1/A2 refers to the UGT2A1/UGT2A2 cluster. Genes taken from NCBI “GeneView.” SNP positions from GRCh37.
| SNP | Chr | Position | Gene | Minor Allele Frequency | COGEND P-Value | OR (95% CI) | COGEND CPD P-Value | Minor Allele Frequency | ACS P value | OR (95% CI) |
|---|---|---|---|---|---|---|---|---|---|---|
| rs1736560 | 1 | 171059150 | FMO3 | 0.30 | 0.0307 | 1.18 (1.02 – 1.38) | 0.0668 | |||
| rs4433435 | 1 | 171223951 | FMO1 | 0.40 | 0.0094 | 0.83 (0.72 – 0.95) | 0.0288 | |||
| rs10912675* | 1 | 171227216 | FMO1 | 0.28 | 0.0065 | 0.80 (0.68 – 0.94) | 0.0578 | 0.27 | 0.0067 | 0.85 (0.75 – 0.96) |
| rs742350^ | 1 | 171250044 | FMO1 | 0.14 | 0.0019 | 0.72 (0.58 – 0.88) | 0.0083 | 0.14 | 0.2205 | 0.91 (0.78 – 1.06) |
| rs1126692^ | 1 | 171252287 | FMO1 | 0.14 | 0.0014 | 0.71 (0.58 – 0.88) | 0.0065 | 0.14 | 0.2160 | 0.91 (0.78 – 1.06) |
| rs7877* | 1 | 171254890 | FMO1 | 0.28 | 0.0011 | 0.77 (0.65 – 0.90) | 0.0128 | 0.27 | 0.0192 | 0.87 (0.77 – 0.98) |
| rs16864387^ | 1 | 171283843 | FMO4 | 0.14 | 0.0013 | 0.71 (0.58 – 0.88) | 0.0070 | 0.14 | 0.2037 | 0.90 (0.89 – 1.05) |
| rs7682207# | 4 | 69771283 | UGT2A3 | 0.13 | 0.0432 | 0.80 (0.64 – 0.99) | 0.1146 | |||
| rs12651295# | 4 | 69771935 | UGT2A3 | 0.13 | 0.0390 | 0.80 (0.64 – 0.99) | 0.0981 | |||
| rs3775783 | 4 | 70463854 | UGT2 A1/A2 | 0.20 | 0.0362 | 0.82 (0.69 – 0.99) | 0.1889 |
*,^, #
These SNPs are correlated (r2) 0.8 or greater.
COGEND = Collaborative Genetic Study of Nicotine Dependence
CPD = Cigarettes per day
ACS=American Cancer Society