Figure 3.

Effects of l-NNA (1 mM) and MRS 2179 (20 μM) on the 15 V-electrical field stimulation-induced relaxation of the ileal longitudinal muscle layer in the presence of atropine 1 μM. (a) Representative mechanical recordings showing the sequential reversal of the relaxation with the addition of these drugs in both orders. (b) Bar diagrams showing the inhibition of the initial level of relaxation, in terms of latency, after administration of l-NNA followed by MRS 2179 (upper panel) and MRS 2179 followed by l-NNA (lower panel) in preparations from control (left panel) and diabetic animals (right panel).