Table 1.
Cell surface markers showing abnormal expression on B cells after haematopoietic stem cell transplantation (HSCT)
| Antigen | Number of cells* | Comments | References |
|---|---|---|---|
| mIgM | A | High levels of membrane bound IgM on B cells post-HSCT | [98–100] |
| mIgD | A | Slightly increased levels of membrane-bound IgD post-HSCT | [98] |
| Few mIgD- class-switched cells 1 year after transplantation | [21] | ||
| CD1c | + | Increased numbers first year post-HSCT | [97] |
| CD5 | + | Increased numbers first year post-HSCT | [96–98,101] |
| Increased expression of IgM, CD20 and HLA-DR on CD5+ B cells | [101] | ||
| Normal expression of CD11a, CD44, CD54 and CD62L on CD5+ B cells | [102] | ||
| N | Normal numbers first year post-HSCT | [103] | |
| CD10 | + | Increased numbers post-HSCT | [95,104,105] |
| N | Normal numbers post-HSCT | [97,103,106] | |
| CD11a | − | Decreased numbers of CD5- B cells that express CD11a 4 months after transplantation | [102] |
| CD21 | − | Decreased numbers first half-year post-GSCT | [27,93,98,99,105] |
| N | Normal numbers of cells first 10 months post-HSCT | [97,103] | |
| CD23 | − | Low numbers first half-year post-HSCT, then normal or slightly increased numbers of cells | [26] |
| + | Increased numbers of cells first 10 months, then normal numbers | [97,103,104] | |
| N | Normal numbers early and late post-HSCT | [98] | |
| CD27 | − | Low numbers post-HSCT. Both IgM+ and class-switched cells affected | [20,91–94] |
| CD38 | + | Increased numbers first half-year post-HSCT | [97–99,106] |
| CD44 | − | Low numbers of CD5- B cells that express CD44 4 months after transplantation | [102] |
| CD54 | − | Low numbers of CD5- B cells that express CD54 4 months after transplantation | [102] |
| CD62L | – | Low numbers first 10 months | [98,103] |
| Low numbers of CD5- B cells express CD62L 4 months after transplantation | [102] | ||
| N | Normal numbers post-HSCT | [97] | |
| HLA-DR | N | Normal numbers post-HSCT | [97,106] |
*
The number of B cells in blood expressing the respective marker: A: all B cells; N: normal expression compared to healthy controls; −: decreased percentage of B cells in blood compared to healthy control; +: increased percentage of B cells in blood compared to healthy control; HLA-DR: human leucocyte antigen D-relayed; Ig: immunoglobulin.