Table 1.
T cell epitope discovery and responses to herpes simplex virus (HSV) open reading frames (ORFs) in humans, mice and rabbits
| T cells to HSV-1 | T cells to HSV-2 | ||||
|---|---|---|---|---|---|
| ORF | CD4+ | CD8+ | CD4+ | CD8+ | Publication(s) |
| RL1 (ICP34.5) | |||||
| RL2 (ICP0) | Hu | Hu | Hu | [30,37,38,50,54,92] | |
| UL1 (gL) | Hu | [37] | |||
| UL2 | |||||
| UL3 | |||||
| UL4 | |||||
| UL5 | |||||
| UL6 | |||||
| UL7 | Hu | [50] | |||
| UL8 | |||||
| UL9 | Mo-W | [53] | |||
| UL10 (gM) | |||||
| UL11 | Hu | [92] | |||
| UL12 | |||||
| UL13 | Hu | [37] | |||
| UL14 | |||||
| UL15 | |||||
| UL16 | |||||
| UL17 | |||||
| UL18 (VP23) | |||||
| UL19 (VP5) | Hu | Hu | [30,54,92] | ||
| UL20 | |||||
| UL21 | Hu | Hu | [32,37,50] | ||
| UL22 (gH) | Mo-W | [53] | |||
| UL23 (TK) | Hu | [78] | |||
| UL24 | |||||
| UL25 (VP26) | Hu, Mo-T | Hu | [30,37,50,92] | ||
| UL26 (VP21) | Hu | Hu | [37,50] | ||
| UL26.5 (VP22a) | |||||
| UL27 (gB) | Hu | Hu, Mo-W | Hu | Hu | [31,37,53,80,92,93] |
| UL28 (ICP18.5) | Mo-W | [53] | |||
| UL29 (ICP8) | Hu, Mo-W | Hu | [30,37,53] | ||
| UL30 (DNA pol) | |||||
| UL31 | Hu | [37] | |||
| UL32 | |||||
| UL33 | |||||
| UL34 | |||||
| UL35 (VP26) | |||||
| UL36 (VP1/2) | |||||
| UL37 | Hu | [37] | |||
| UL38 (VP19c/ICP32) | |||||
| UL39 (ICP6/ICP10) | Hu, Mo-W | Hu | Hu | [30,37,52–54] | |
| UL40 | Hu, Mo-W | [37,53] | |||
| UL41 (VHS) | Hu, Mo-W | [37,53] | |||
| UL42 | |||||
| UL43 | |||||
| UL44 (gC) | Mo-W | [53] | |||
| UL45 | |||||
| UL46 (VP11/12) | Hu | Hu, Mo-W | Hu, Mo-W | [30,37,39,50,92] | |
| UL47 (VP13/14) | Hu | Mo-W | Hu, Mo-W | [37–39,50] | |
| UL48 (VP16) | Hu | Hu | [32–35,37,94] | ||
| UL49 (VP22) | Hu | Hu, Mo-W | Hu, Mo-W | [30,32,37–39,50,54,92] | |
| UL49A (gN) | |||||
| UL50 (dUTPase) | Hu | [32] | |||
| UL51 | |||||
| UL52 | |||||
| UL53 (gK) | Mo-W | Hu; Mo-W | [37,53,95,96] | ||
| UL54 (ICP27) | Hu | Hu, Mo-W | [37,50,51,97] | ||
| UL55 | |||||
| UL56 | |||||
| US1 (ICP22) | Hu | [37] | |||
| US2 | |||||
| US3 | |||||
| US4 (gG) | Mo-W | [53] | |||
| US5 (gJ) | |||||
| US6 (gD) | Rb-W, Rb-T, Hu | Rb-T, Hu, Mo-T | Hu, Mo-W | Hu, Mo-W, Mo-T | [31,39,43–45,48–50,54,84] |
| US7 (gI) | Hu | [37] | |||
| US8 (gE) | Hu | [50] | |||
| US8A | |||||
| US9 | Hu | [50] | |||
| US10 | |||||
| US11 | |||||
| US12 (ICP47) | |||||
| RS1 (ICP4) | Hu | Hu | Hu | [37,54,92] | |
ORF names per annotation of HSV-1 (NC_001806) and HSV-2 (NC_001798) complete genome sequences. Hu: human; Mo-T: transgenic mouse with human major histocompatibility complex (MHC); Mo-W: mouse with wild-type (mouse) MHC; Rb-T: transgenic rabbit with human MHC; Rb-W: rabbit with wild-type (rabbit) MHC.