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. 2012 Jan;167(1):120–128. doi: 10.1111/j.1365-2249.2011.04492.x

Table 3.

List of the 67 significant genes differentially expressed comparing immune dysregulation, polyendocrinopathy, enteropathy, X-linked (IPEX) patients and their parents. Up-regulated genes in IPEX patients included relevant immune response-related genes; interleukin (IL)-8, IL-18, CD31 and interferon (IFN)-γ-receptor 1, while FcεR-I, signal transducer and activator of transcription-4 (STAT4), CD3δ, CD3ε and CD3ζ, CXCR4 and CCL5 were among the most down-regulated genes

Gene activation*

Probe set Gene symbol Name IPEX Parents Fold change P-value
1 210354_at IFN-G IFN-γ 40·08 106·06 0·38 0·0000008
2 205758_at CD8A CD8a molecule 184·79 752·34 0·25 0·0000028
3 204655_at CCL5 Chemokine (C-C motif) L5 1187·55 3769·35 0·32 0·0000045
4 1405_i_at CCL5 Chemokine (C-C motif) L5 1092·18 3233·23 0·34 0·0000088
5 212501_at CEBPB CCAAT/enhancer binding protein (C/EBP), β 5270·75 2930·74 1·8 0·0000092
6 203685_at BCL2 B cell CLL/lymphoma 2 109·71 302·31 0·36 0·0000102
7 214032_at ZAP70 ζ-chain (TCR)-associated protein kinase 70 kDa 271·16 686·86 0·39 0·0000111
8 206118_at STAT4 Signal transducer and activator of transcription 4 280·86 720·5 0·39 0·0000267
9 211676_s_at IFN-GR1 IFN-γ receptor 1 1446·24 925·76 1·56 0·000039
10 212195_at IL-6ST IL-6 signal transducer (gp130, oncostatin M receptor) 511·1 829·61 0·62 0·0000432
11 211734_s_at FCER1A Fc fragment of IgE, high affinity I, receptor for; α polypeptide 122·17 381·85 0·32 0·0000574
12 211506_s_at IL-8 IL-8 1229·78 700·46 1·76 0·0000608
13 202741_at PRKACB Protein kinase, cAMP-dependent, catalytic, β 590·06 1080·34 0·55 0·0000901
14 208488_s_at CR1 Complement component (3b/4b) receptor 1 (Knops blood group) 471·89 178·43 2·64 0·000195
15 202426_s_at RXRA Retinoid X receptor, α 243·78 148·31 1·64 0·0002419
16 32541_at PPP3CC Protein phosphatase 3 (formerly 2B), catalytic subunit, γ isoform 169·9 279·14 0·61 0·0002587
17 210556_at NFATC3 Nuclear factor of activated T cells, cytoplasmic, calcineurin-dependent 3 235·76 406·52 0·58 0·0003062
18 207334_s_at TGF-BR2 Transforming growth factor, β receptor II (70/80 kDa) 43·52 85·6 0·51 0·0003105
19 208637_x_at ACTN1 Actinin, α 1 335·43 201·62 1·66 0·0003203
20 214617_at PRF1 Perforin 1 (pore forming protein) 1949·45 3816·41 0·51 0·0003764
21 205831_at CD2 CD2 molecule ′435·7 1111·33 0·39 0·0003955
22 205798_at IL7R IL-7 receptor 1083·05 3854·88 0·28 0·0004234
23 206170_at ADRB2 Adrenergic, β-2, receptor, surface 71·89 135·33 0·53 0·0004319
24 201329_s_at ETS2 v-ets erythroblastosis virus E26 oncogene homologue 2 (avian) 423·64 238·09 1·78 0·0005064
25 202859_x_at IL8 IL-8 3278·21 2057·88 1·59 0·000712
26 210031_at CD247 CD247 molecule 939·33 1980·45 0·47 0·0007122
27 208981_at PECAM1 Platelet/endothelial cell adhesion molecule (CD31 antigen) 1539·05 973·44 1·58 0·0007861
28 204790_at SMAD7 SMAD family member 7 43·78 119·01 0·37 0·0008775
29 204891_s_at LCK Lymphocyte-specific protein tyrosine kinase 683·74 1624·99 0·42 0·0009013
30 215223_s_at SOD2 Superoxide dismutase 2, mitochondrial 1776·67 883·36 2·01 0·0010719
31 202201_at BLVRB Biliverdin reductase B [flavin reductase (NADPH)] 1247 718·53 1·74 0·0010769
32 206099_at PRKCH Protein kinase C, η 210·75 419·15 0·5 0·0011349
33 205159_at CSF2RB CSF2 R, β (granulocyte-macrophage) 1594·02 837·8 1·9 0·0012975
34 220034_at IRAK3 IL-1 receptor-associated kinase 3 233·17 134·12 1·74 0·0013425
35 208636_at ACTN1 Actinin, α 1 627·36 341·48 1·84 0·0014019
36 202742_s_at PRKACB Protein kinase, cAMP-dependent, catalytic, β 294·34 510·06 0·58 0·0016042
37 212249_at PIK3R1 Phosphoinositide-3-kinase, regulatory subunit 1 (p85 α) 299·47 539·65 0·55 0·0016352
38 204890_s_at LCK Lymphocyte-specific protein tyrosine kinase 371·51 864·54 0·43 0·0016548
39 206244_at CR1 Complement component (3b/4b) receptor 1 (Knops blood group) 243·02 105·49 2·3 0·0018088
40 202789_at PLCG1 Phospholipase C, γ 1 102·32 224·48 0·46 0·001989
41 210038_at PRKCQ Protein kinase C, θ 266·17 666·04 0·4 0·0020766
42 207000_s_at PPP3CC Protein phosphatase 3 (formerly 2B), catalytic subunit, γ isoform 159·99 280·98 0·57 0·0021735
43 211919_s_at CXCR4 Chemokine (CXC motif) receptor 4 2143·05 3372 0·64 0·0022819
44 203749_s_at RARA Retinoic acid receptor, α 201·54 137·24 1·47 0·00261
45 206341_at IL-2RA IL-2 receptor, α 26·57 47·78 0·56 0·0029684
46 218764_at PRKCH Protein kinase C, eta 539·32 1044·76 0·52 0·0035346
47 206295_at IL-18 IL-18 (IFN-γ-inducing factor) 101·68 67·22 1·51 0·0038569
48 203680_at PRKAR2B Protein kinase, cAMP-dependent, regulatory, type II, β 279·27 182·61 1·53 0·0039945
49 209545_s_at RIPK2 Receptor-interacting serine-threonine kinase 2 725·53 520·11 1·39 0·0040329
50 205321_at EIF2S3 Eukaryotic translation initiation factor 2, subunit 3 γ, 52 kDa 381·03 593·83 0·64 0·0042516
51 217028_at CXCR4 Chemokine (CXC motif) receptor 4 3897·23 5792·91 0·67 0·0047524
52 212239_at PIK3R1 Phosphoinositide-3-kinase, regulatory subunit 1 (p85 α) 514·72 969·17 0·53 0·0053206
53 217281_x_at IL-8 IL-8 91·46 47·08 1·94 0·0053833
54 214732_at SP1 Sp1 transcription factor 53·16 32·09 1·66 0·0055414
55 217552_x_at CR1 Complement component (3b/4b) receptor 1 (Knops blood group) 755·77 221·14 3·42 0·0057036
56 210039_s_at PRKCQ Protein kinase C, theta 163·02 344·84 0·47 0·0057336
57 216033_s_at FYN FYN oncogene related to SRC, FGR, YES 869·01 1260·7 0·69 0·0059456
58 209201_x_at CXCR4 Chemokine (CXC motif) receptor 4 1645·65 2668·73 0·62 0·0059718
59 204731_at TGF-BR3 Transforming growth factor, β receptor III 394·58 829·35 0·48 0·0060871
60 205456_at CD3E CD3e molecule, epsilon (CD3–TCR complex) 293·32 722·44 0·41 0·0062648
61 210145_at PLA2G4A Phospholipase A2, group IVA (cytosolic, calcium-dependent) 52·4 35·04 1·5 0·0067767
62 209615_s_at PAK1 p21/Cdc42/Rac1-activated kinase 1 (STE20 homologue, yeast) 212·87 152·72 1·39 0·0067792
63 201328_at ETS2 v-ets erythroblastosis virus E26 oncogene homologue 2 (avian) 414·19 220·44 1·88 0·0068566
64 204852_s_at PTPN7 Protein tyrosine phosphatase, non-receptor type 7 108·76 170·37 0·64 0·0069018
65 201017_at EIF1AX Eukaryotic translation initiation factor 1A, X-linked 177·87 324·3 0·55 0·0069616
66 213539_at CD3D CD3d molecule, δ (CD3–TCR complex) 700·22 1956·46 0·36 0·0080763
67 218284_at SMAD3 SMAD family member 3 148·87 215·06 0·69 0·0089997
*

Geometric mean of detected fluorescence. NAPDH: nicotinamide adenine dinucleotide phosphate; cAMP: cyclic adenosine-5′-monophosphate; TCR: T cell receptor.