Fig. 3.

Plasma CXCL10 (3–77) concentrations are higher in chronic patients than in sustained virological responder (SVR) VR patients. (a) Plasma samples were obtained from hepatitis C virus (HCV) patients and concentration of CXCL10 (total), CXCL10 (1–77) and CXCL10 (3–77) were analysed. The donor with the highest level of CXCL10 (total) is marked in orange with corresponding symbols indicated for the respective assays. (b) The calculated fraction of truncated CXCL10 is represented [% truncated CXCL10 = [(CXCL10 (total) – CXCL10 (1–77))/CXCL10 (1–77)]. (c,d) Plasma CXCL10 (3–77) concentration and the percentage of truncated CXCL10 is shown for the two patient groups – chronic versus SVR. A Mann–Whitney U-test was used to compare the two groups and, where significant, P-value is indicated. Dotted red lines indicate the lower assay limit (LAL) for the respective assays. Solid blue line indicates the percentage of CXCL10 (3–77) that is capable of exerting a dominant negative effect on CXCR3.