Fig. 5.

Urinary CXCL10 in bacilli Calmette–Guérin (BCG) treatment patients exists in a truncated form. Samples were obtained from bladder cancer patients during their fifth instillation of BCG. (a) Pre- and 4 h post-BCG urines were collected and CXCL10 three-plex was performed. Dotted red lines indicate the lower assay limit (LAL) for the respective assays, preformed using a proprietary buffer for measurements of urine samples. Note that the LAL for urine assays was lower than for plasma assays. At the 4-h time-point, three representative patients are marked in green, orange or blue to allow tracking of total, long and short CXCL10 concentrations. (b) Kinetic studies are shown for two patients (CXCL10 total, blue; 1–77, black; and 3–77, red).