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. 2010 Nov 16;1(7):483–496. doi: 10.18632/oncotarget.185

Figure 1. Application of lineage-associated immunohistochemical markers in MDS.

Figure 1

Bone marrow sections obtained from patients with MDS stained with antibodies against CD34 (A, B), CD42b (C), tryptase (D), 2D7 (E), and eosinophil major basic protein, EMBP (F). The CD34 stain is useful for detection of immature precursor cells (blast cells) in patients with RAEB (A). Megakaryocytes and megakaryoblasts may also stain positive for CD34 in MDS (B). A preferred marker of the megakaryocyte lineage is, among other, CD42b (C). The tryptase stain may reveal an increase in mast cells (D), whereas 2D7 (E) is specific for basophils, and EMBP (F) is useful for the visualization of eosinophils in patients with MDS.