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Most frequent clinical complications in MPN patients are thrombosis, whereas hemorrhage is above all observed in essential thrombocythemia (ET) patients. ET may slowly develop into polycythemia vera (PV), especially if it carries the JAK2 (V617F) mutation. PV and ET may progress to myelofibrosis (post-ET, post-PV MF) and then turn into acute myeloid leukemia (AML), although they may evolve into AML even without showing a MF phase.
