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IRF7 decreases IL-6 mRNA stability. THP1 cells were transfected with IRF7 siRNA, stimulated with poly (I-C) and harvested at various time points after treatment with actinomycin D to block transcription and determine half-life of IL-6 mRNA. IRF7 deficiency decreased the half-life of IL-6 mRNA from 2.2 h to 0.69 h (p < 0.04; n=3).
