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. Author manuscript; available in PMC: 2012 Aug 10.
Published in final edited form as: Cell Immunol. 2011 Aug 10;271(2):342–349. doi: 10.1016/j.cellimm.2011.07.014

Table 1.

Distinct roles for IRF in poly (I-C) induced gene expression in human cell lines

Fibroblast-like synoviocyte THP1 Monocyte
IRF3

  • Regulates IFN response genes: IFNβ, IP-10, MCP1, RANTES, MIP1α

  • Activates ISRE, AP-1

  • Regulates IL-6, IL-8, MMP

  • Regulates IFN response genes: IFNβ, IP-10, MCP1, RANTES, MIP1α

  • Activates ISRE
IRF5 Not determined

  • Regulates IFN response genes: IFNβ, IP-10, MCP1, RANTES

  • Activates ISRE

  • Regulates IL-6
IRF7 No effect

  • Regulates IFN response genes: IFNβ, IP-10

  • Activates ISRE

  • Regulates IL-6