Table 3.
Baseline characteristics [mean (SD)] and adjusted muscle mass and strength measures [LS means] by PTH quartiles in an age-stratified sample of 311 men and 356 women from Rochester, Minnesota
| Characteristics | Total (N=311) |
Men PTH (pmol/L) |
p value | Total (N=356) |
Women PTH (pmol/L) |
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 0.5-2.5 (N=75) |
2.6-3.4 (N=75) |
3.5-4.5 (N=78) |
4.6-15.0 (N=83) |
0.5-2.5 (N=106) |
2.6-3.4 (N=80) |
3.5-4.5 (N=91) |
4.6-15.0 (N=79) |
|||||
| Age, yrs | 56.3 (18.5) | 51.2 (18.7) | 52.2 (17.4) | 56.0 (17.8) | 64.9 (17.4) | <0.001 | 57.2 (17.7) | 52.9 (18.9) | 57.3 (16.7) | 57.7 (18.1) | 62.4 (15.1) | <0.001 |
| Height, m | 1.8 (0.1) | 1.8 (0.1) | 1.8 (0.1) | 1.8 (0.1) | 1.8 (0.1) | 0.324 | 1.6 (0.1) | 1.6 (0.1) | 1.6 (0.1) | 1.6 (0.1) | 1.6 (0.1) | 0.148 |
| BMI, Kg/m2 | 28.5 (4.6) | 28.4 (4.7) | 28.3 (4.4) | 28.9 (4.6) | 28.5 (4.8) | 0.687 | 27.9 (6.3) | 26.1 (5.1) | 27.7 (5.7) | 28.6 (6.7) | 29.6 (7.1) | <0.001 |
| Fat mass, kg | 30.1 (11.0) | 29.4 (10.5) | 29.1 (12.1) | 31.5 (11.2) | 30.4 (10.4) | 0.324 | 33.6 (13.0) | 29.8 (12.1) | 34.5 (12.2) | 35.5 (14.1) | 36.1 (12.8) | <0.001 |
| Physical activity, total Kcal/week | 36462.3 (12516.8) |
37425.8 (14773.0) |
37242.0 (11590.5) |
37585.9 (13212.3) |
33792.2 (10007.6) |
0.090 | 27533.5 (9275.3) |
27513.2 (8577.0) |
26803.4 (6983.8) |
29008.5 (11755.8) |
26567.3 (8841.4) |
0.937 |
| Season (Nov-Feb), N [%] | 71 [22.8] | 26 [34.7] | 16 [21.3] | 15 [19.2] | 14 [16.9] | 0.010 | 155 [43.5] | 50 [47.2] | 39 [48.8] | 33 [36.3] | 33 [41.8] | 0.210 |
| 25(OH)D, ng/mL | 23.0 (8.3) | 24.9(9.4) | 25.6(8.2) | 22.3(7.5) | 19.6(6.5) | <0.001 | 22.1 (10.0) | 26.6 (10.6) | 21.6 (8.5) | 21.9 (9.8) | 16.7 (7.9) | <0.001 |
| 1,25(OH)D, pg/mL | 40.8 (13.3) | 38.2(13.0) | 45.3(13.0) | 41.8(14.0) | 38.2(12.0) | 0.520 | 38.4 (15.0) | 39.7 (15.8) | 38.7 (13.9) | 39.7 (16.1) | 34.9 (12.9) | 0.070 |
| Skeletal muscle mass, Kg | ||||||||||||
| Unadjusted model | 33.2 (5.3) | 33.56 | 34.25 | 32.96 | 31.95 | 0.021 | 20.0 (3.2) | 19.91 | 20.80 | 19.85 | 19.47 | 0.210 |
| Age and Height adjusted | 32.86 | 33.68 | 33.06 | 33.01 | 0.925 | 19.78 | 20.40 | 19.94 | 19.99 | 0.778 | ||
| Age, Height , PA, season and FM adjusted | 32.94 | 33.78 | 32.94 | 33.23 | 0.995 | 19.97 | 20.50 | 19.74 | 19.86 | 0.377 | ||
| Handgrip force, N | ||||||||||||
| Unadjusted model | 428.7 (96.2) | 442.09 | 451.04 | 421.98 | 402.69 | 0.002 | 238.9 (54.5) | 245.03 | 238.55 | 235.30 | 235.13 | 0.178 |
| Age adjusted | 427.39 | 439.05 | 421.36 | 427.52 | 0.679 | 238.63 | 238.67 | 236.10 | 242.68 | 0.725 | ||
| Age, PA, season and FM adjusted | 424.54 | 441.08 | 420.52 | 429.35 | 0.867 | 236.80 | 240.07 | 236.39 | 245.19 | 0.384 | ||
| Isometric knee extension moment, Nm | ||||||||||||
| Unadjusted model | 172.2 (58.7) | 183.62 | 183.53 | 170.92 | 152.71 | <0.001 | 93.7 (28.8) | 95.25 | 98.71 | 92.63 | 87.28 | 0.045 |
| Age adjusted | 171.01 | 175.89 | 171.04 | 170.79 | 0.809 | 91.37 | 98.85 | 92.87 | 92.23 | 0.923 | ||
| Age, PA, season and FM adjusted | 170.10 | 176.90 | 170.64 | 172.32 | 0.994 | 91.82 | 98.91 | 92.74 | 90.72 | 0.523 | ||
| Normalized knee extension moment | ||||||||||||
| Unadjusted model | 0.178 (0.050) | 0.189 | 0.185 | 0.179 | 0.160 | <0.001 | 0.162 (0.039) | 0.163 | 0.163 | 0.165 | 0.154 | 0.203 |
| Age adjusted | 0.180 | 0.180 | 0.179 | 0.174 | 0.373 | 0.158 | 0.163 | 0.166 | 0.159 | 0.624 | ||
| Age, PA, season and FM adjusted | 0.178 | 0.180 | 0.180 | 0.174 | 0.577 | 0.158 | 0.163 | 0.166 | 0.160 | 0.553 | ||
Note: BMI=body mass index; PTH=parathyroid hormone; PA=physical activity; FM=fat mass; p-values are from tests for trend