Table 1.
Pharmacodynamic index correlated with maximal efficacy of selected antimicrobials
| Pharmacodynamic index | f T>MIC | Cmax/MIC | AUC0–24/MIC |
|---|---|---|---|
| Antimicrobials | β-Lactams | Aminoglycosides | Fluoroquinolones |
| Carbapenems | Metronidazole | Aminoglycosides | |
| Linezolid | Fluoroquinolones | Azithromycin | |
| Erythromycin | Telithromycin | Tetracyclines | |
| Clarithromycin | Daptomycin | Glycopeptides | |
| Lincosamides | Tigecycline | ||
| Linezolid |
f T>MIC, time dependent antimicrobials; Cmax/MIC, concentration-dependent antimicrobials; AUC0–24/MIC, concentration-dependent antimicrobials with time dependence.