Table 2.
Base models for S- and R-warfarin
| S-Warfarin | R-Warfarin | |||||
|---|---|---|---|---|---|---|
| Objective function | 8975 | 9425 | ||||
| Parameter | Estimate | Standard error | 95% Confidence interval | Estimate | Standard error | 95% Confidence interval |
| CL (l h−1) | 0.149 | 0.00465 | (0.140, 0.158) | 0.132 | 0.00381 | (0.125, 0.139) |
| V (l) | 15.2 | 1.64 | (12.0, 18.4) | 9.11 | 0.934 | (7.28, 10.9) |
| Ka | 1.66 | Fixed | – | 1.66 | Fixed | – |
| IIV CL* | 49.3% | (43.7%, 54.3%) | 47.3% | (41.1%, 52.8%) | ||
| IIV V* | 38.6% | (5.46%, 54.3%) | 56.5% | (38.3%, 74.7%) | ||
| Proportional error* | 30.1% | (25.3%, 34.2%) | 31.9% | (29.2%, 34.5%) | ||
| Additive error (µg ml−1) | 45.8 | (–40.8, 76.6) | 1 | Fixed | – | |
*
Interindividual variability (IIV) and residual proportional error are expressed as an approximate coefficient of variation (square root of the variance). Ka, absorption rate.