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. 2011 Dec 27;122(1):267–279. doi: 10.1172/JCI44927

Figure 7. Txnip-KO hearts increase anaerobic metabolism under hypoxia.

Figure 7

(A) Txnip-KO hearts had significantly improved mechanical function during hypoxia (95% N2, 5% CO2) and recovery (95% O2, 5% CO2). Hearts were perfused in a Langendorff heart model system in the presence of glucose (5.5 mM), mixed long-chain fatty acids (0.4 mM bound to 1% albumin), DL-β-hydroxybutyrate (0.38 mM), lactate (1 mM), and insulin (50 μU/ml). (B) To inhibit cellular glycolysis, hearts were perfused with oxamate (50 mM), a competitive inhibitor of LDH. n = 3 per group. Values are mean ± SEM. *P < 0.05, **P < 0.01 versus WT.