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. 2011 Dec 27;122(1):348–358. doi: 10.1172/JCI58878

Figure 5. Cd151 influences localization of α3 in vitro and in vivo.

Figure 5

(A) TIRF microscopy of GECs seeded on laminin-332 showed integrin α3 in large vinculin-positive focal adhesions only in the absence of Cd151 (arrowheads). (B) Absence of Cd151 in podocytes of healthy 12-week-old B6/FVB mice led to diffuse membranous distribution of α3. Recombination of the mT/mG reporter allele and subsequent expression of membrane-targeted GFP was indicative of Cre activity and outlined podocyte membranes. Scale bar: 100 μm (B, top row), 20 μm (A and B, bottom rows).