Fig. 5.

Expression of a constitutively active FXR rescues promotes lung repair in FXR−/− mice. FXR−/− mice were infected by iv injection with either a control VP-16 adenovirus or an adenovirus that expresses FXR-VP16. After 4 d, the mice were treated with vehicle control (Con) or LPS (4 μg/10 g of BW). A, Lung vascular permeability was measured at the indicated time points [d 1 (D1), and d 2 (D2)] after LPS treatment. B, Quantification of BrdU-positive nuclei. C–H, Relative mRNA levels of Foxm1b (C), TNFα (D), IFNγ (E), iNOS (F), MCP1 (G), and P-selectin (H) as measured by RT-QPCR using total RNA prepared from the whole lung. *, P < 0.05. Con, Control.