Table 1.
N | % | ||
---|---|---|---|
Total | 67 | ||
Median age (range) | |||
| |||
≥18years | 33 (18–72) | 53 | |
| |||
<18 years: | 10.4 (3–16) | 14 | |
Sex | |||
| |||
Male | 36 | 53 | |
| |||
Female | 28 | 41 | |
Clinical conditions at Diagnosis | |||
| |||
Bleeding | 53 | 79 | |
| |||
Febrile neutropenia | 5 | 7 | |
| |||
HCV | 1 | 1.5 | |
| |||
Transfusion | |||
| |||
Blood Transfusion | 66 | 98 | |
| |||
Platelet transfusion | 63 | 94 | |
Organomegaly | |||
| |||
Hepatomegaly | 6 | 9 | |
| |||
Splenomegaly | 7 | 10 | |
WBC count | |||
| |||
WBC≥10 (x 109/L) | 23 | 34 | |
| |||
WBC<10 (x 109/L) | 44 | 66 | |
Platelet Count | |||
| |||
≥40 (x 109/L) | 16 | 24 | |
| |||
<40 (x 109/L) | 51 | 76 | |
Sans Risk category | |||
| |||
Low risk | 11 | 16 | |
| |||
Intermediate risk | 33 | 49 | |
| |||
High Risk | 23 | 34 | |
| |||
Total | 67 | ||
Bone Marrow Cellularity | |||
| |||
Hypocellular | 26 | 39 | |
| |||
Hypercellular | 17 | 25 | |
| |||
Normal cellular | 24 | 36 | |
| |||
FLT3-ITD (only in 14 patients) | |||
| |||
Wild | 11 | 79 | |
| |||
FLT3-ITD mutation | 3 | 21 | |
Induction Treatment | n=62 | ||
| |||
Doxorubicin or Idarubicin + ATRA | 51 | 82 | |
| |||
Pediatric protocol | 11 | 18 | |
Induction Complications | |||
| |||
Bleeding | 11 | 18 | |
| |||
Febrile neutropenia | 26 | 42 | |
| |||
Differentiation syndrome | 7 | 11 | |
| |||
Heart failure | 1 | 1.6 | |
Death during induction | 3 | 4.47 | |
Consolidation regimen | n=59 | ||
| |||
Doxorubicin + ATRA | 47 | 80 | |
| |||
Pediatric protocol | 12 | 20 | |
Consolidation Complication | |||
| |||
Febrile neutropenia | 9 | 15 | |
| |||
Death | 1 | 1.49 | |
Maintenance treatment | n=58 | ||
Median survival mo | 19.23 | ||
(95% CI) | (16.33–23.75) |