Table 3.

Risk of therapy-related myeloid neoplasms in breast cancer patients receiving radiotherapy.

Reference	Breast cancer patients (n)	Therapy	t-MN (n)	Cumulative risk (%)
Renella et al, 2006 [33]	2292	Radiotherapy alone	7	1.9
	1119	Radiotherapy + chemotherapy	2	1.7
Howard et al, 2007 [4]	99275	Radiotherapy alone	221	0.22 (at 10 y)
Hershman et al, 2007 [40]	2837	Radiotherapy alone	38	1.33
Schaapveld et al, 2008 [5]	31000	Radiotherapy alone	13	1.28 (at 10 y)
Martin et al, 2009 [3]	420076	Radiotherapy +/− chemotherapy	450	0.91 (at 5 y) for range 15–49 years; 1.14 (at 5 y) for range 50–64 years; 1.76 (at 5 y) for >65 years
Zhang et al, 2011 [41]	1779	Radiotherapy alone	7	6.67 (at 4.5 y)
	553	Radio- + hormonal therapy
	293	Radio- + chemotherapy
	25	Radio- + hormonal+chemotherapy
	2650	Total