Figure 4. Influence of Noise Regression Methods on the Comparisons of Genetic Groups.

A linear increase with with rs1006737 genotype in functional coupling between the right DLPFC (seed voxel) and the right hippocampus is detected for both noise reduction algorithms. However, the interpretation of the changes depending on the underlying correlation profile. While in the “standard implementation” one would argue that the hippocampus is decoupled in GG carriers and that coupling increases with genetic risk (GG<GA<AA), after global normalization the results suggest that medial temporal areas are anticorrelated with the DLPFC and at increasing genetic risk this negative coupling is downregulated.