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. Author manuscript; available in PMC: 2011 Dec 29.
Published in final edited form as: Annu Rev Immunol. 2009;27:339–362. doi: 10.1146/annurev.immunol.021908.132554

Figure 1.

Figure 1

Alignment of transmembrane and cytoplasmic regions of leukocyte integrins. Data is taken from UniProt (www.uniprot.org), and amino acid numbering does not include the signal sequence. The solid orange box indicates the transmembrane domain predicted by the Hidden Markov model (121). The open red box indicates residues that were experimentally determined to be within the lipid bilayer (122). Residues boxed in yellow are important for the salt bridge linking the α and β integrin tails. The purple boxes indicate the two NPXY/F motifs in the β integrin tails.