Figure 3. RA signalling activity in DMBA-induced tumours (A–B) and in LSL-KrasG12D/+;LSL-Trp53R172H/+;Pdx1-Cre;RARE-LacZ pancreatic tumours (C–D) and mPanIN lesions (E–F).

In tumors from DMBA treated RARE-LacZ mice, a distinct absence of any cells exhibiting active retinoid signaling was observed (B). In LSL-KrasG12D/+;LSL-Trp53R172H/+;Pdx1-Cre;RARE-LacZ pancreatic tumours and precursor lesions, there was also a complete absence of retinoid signaling activity (D and F respectively).