. 2011 Dec 29;6(12):e29418. doi: 10.1371/journal.pone.0029418

Table 4. Down-regulation of P450 genes in adults of permethrin selected offspring of the field populations of Culex quinquefasciatus.

			Relative Gene expression ± SE^b
Mosquitoes	Transcript ID^a	Gene	Parental strain^c	Resistant strain^d		Ratio^e
HAmCq (14)	CPIJ008972^# ^§	CYP6F5P	0.8±0.02		0.4±0.04	−2.0
	CPIJ010547^#	CYP9J47	2.0±0.01		0.9±0.2	−2.2
	CPIJ016849	CYP6M12	5.1±0.9		2.2±0.5	−2.3
	CPIJ003376	CYP6BY4	1.9±0.4		0.8±0.1	−2.4
	CPIJ005332	CYP9J43	3.2±0.1		1.2±0.2	−2.7
	CPIJ000294^*	CYP4J13	1.6±0.09		0.6±0.1	−2.7
	CPIJ010542	CYP9J38	0.8±0.1		0.3±0.2	−2.7
	CPIJ006951	CYP325BG2P	1.1±0.4		0.4±0.1	−2.8
	CPIJ014730	CYP325AA2	0.6±0.2		0.2±0.1	−3.0
	CPIJ009473^#	CYP4D41	3.3±0.2		0.9±0.04	−3.7
	CPIJ007093	CYP325Y8	2.3±0.3		0.6±0.06	−3.8
	CPIJ005683^#	CYP325Y10	2.7±0.2		0.5±0.2	−5.4
	CPIJ010480	CYP4J20	1.1±0.2		0.1±0.04	−11
	CPIJ003375^* ^#	CYP6BY3	0.4±0.04		0.02±0.007	−20
MAmCq (9)	CPIJ001757^#	CYP4H39	1.7±0.1		0.8±0.1	−2.1
	CPIJ019765^#	CYP9M14	2.3±0.4		1.1±0.3	−2.1
	CPIJ017245	CYP304B6	1.3±0.3		0.6±0.06	−2.2
	CPIJ010545	CYP9J41	1.4±0.3		0.6±0.02	−2.3
	CPIJ003375^* ^#	CYP6BY3	0.7±0.02		0.3±0.03	−2.3
	CPIJ000294^*	CYP4J13	1.3±0.2		0.5±0.05	−2.6
	CPIJ017242	CYP304C1	2.9±0.3		1.1±0.1	−2.6
	CPIJ010538	CYP9J46	0.02±0.01		0.005±0.003	−4.0
	CPIJ001810^#	CYP4C38	2.3±0.1		0.1±0.02	−23

The transcript ID number from the vectorbase of the Cx. quinquefasciatus genome sequence (http://cquinquefasciatus.vectorbase.org/).

The relative level of gene expression represents the ratio of the gene expression in each resistant strain compared with that in the susceptible S-Lab strain. The relative level of gene expression for S-Lab is 1.

Parental strain for HAmCq population is HAmCq^G0 and for MAmCq population is MAmCq^G0.

Permethrin selected strain for HAmCq population is HAmCq^G8 and for MAmCq population is MAmCq^G6.

The ratio of the relative gene expression in each permethrin selected strain compared its parental strain.

The genes that are down-regulated in both adult of HAmCq^G8 and MAmCq^G6.

The genes that are down-regulated in both larvae and adults of each of HAmCq^G8 and MAmCq^G6, or both

^§

pseudogene.