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. 2011 Dec 29;6(12):e29758. doi: 10.1371/journal.pone.0029758

Table 1. Fold change and functional classification of Twist1 candidate target genes with the most decreased gene expression in siTwist1 vs. siScr transfected MC3T3-E1 cells.

Adhesion-Migration
Ref Seq Gene ID Gene Name Fold Change
NM_013657 Sema3C Semaphorin 3C −4.95
NM_023279 Tubb3 Tubulin, beta 3 −4.27
NM_010717 Limk1 LIM-domain containing, protein kinase −2.74
NM_145953 Cth Cystathionase (cystathionine gamma-lyase) −2.60
NM_010833 Msn Moesin −2.19
NM_008659 Myo1c Myosin IC −2.16
NM_001081053 Itga10 Integrin, alpha 10 −2.12
NM_053083 Loxl4 Lysyl oxidase-like 4 −2.06
NM_011693 Vcam1 Vascular cell adhesion molecule 1 −2.09
Extracellular Matrix
NM_015734 Col5a1 Procollagen, type V, alpha 1 −2.99
NM_011434 Sod1 Superoxide dismutase 1, soluble −2.42
NM_007729 Col11a1 Procollagen, type XI, alpha 1 −2.40
NM_025711 Aspn Asporin −2.30
NM_010917 Nid1 Nidogen 1 −2.21
NM_010721 Lmnb1 Lamin B1 −2.17
NM_008695 Nid2 Nidogen 2 −2.12
Signaling Molecules
NM_011452 Serpinb9b Serine (or cysteine) peptidase inhibitor, clade B, member 9b −3.41
NM_175093 Trib3 Tribbles homolog 3 (Drosophila) −2.95
NM_146162 Tmem119 Transmembrane protein 119 −2.54
NM_028744 Pi4k2b Phosphatidylinositol 4-kinase type 2 beta −2.53
NM_019681 Freq Frequenin homolog (Drosophila) −2.25
NM_024454 Rab21 RAB21, Member RAS oncogene family −2.18
NM_009369 Tgfbi Transforming growth factor, beta induced −2.17
NM_021532 Dact1 Dapper homolog 1, antagonist of beta-catenin (xenopus) −2.20
NM_008924 Prkar2a Protein kinase, cAMP dependent regulatory, type II alpha −2.12
NM_025954 Pgp Phosphoglycolate phosphatase −2.07
NM_008845 Pip4k2a Phosphatidylinositol-5-phosphate 4-kinase, type II, alpha −2.05
Cell Cycle-Proliferation
NM_007836 Gadd45a Growth arrest and DNA-damage-inducible 45 alpha −4.13
NM_021288 Tyms Thymidylate synthase −3.91
NM_175122 Rab39b RAB39B, Member RAS oncogene family −3.64
NM_011119 Pa2g4 Proliferation-associated 2G4 −3.13
NM_010937 Nras Neuroblastoma ras oncogene −2.73
NM_010485 Elavl1 ELAV (Embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R) −2.62
NM_145953 Cth Cystathionase (cystathionine gamma-lyase) −2.60
NM_011641 Trp63 Transformation related protein 63 −2.40
NM_009234 Sox11 SRY-box containing gene 11 −2.25
NM_001081323 Mphosph9 M-phase phosphoprotein 9 −2.25
NM_009906 Tpp1 Tripeptidyl peptidase I −2.24
NM_054102 Ivns1abp Influenza virus NS1A binding protein −2.22
NM_024184 Asf1b ASF1 Anti-silencing function 1 homolog B (S. cerevisiae) −2.15
NM_009881 Cdyl Chromodomain protein, Y chromosome-like −2.12
NM_008726 Nppb Natriuretic peptide precursor type B −2.11
NM_007788 Csnk2a1 Casein kinase 2, alpha 1 polypeptide −2.04
NM_020618 Smarce1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1 −2.00
NM_010067 Trdmt1 tRNA aspartic acid methyltransferase 1 −2.00