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. 2011 Dec 29;6(12):e29492. doi: 10.1371/journal.pone.0029492

Figure 2. Increased serum IL-15 levels are associated with more severe disease activity during the follow-up of patients with Early Arthritis.

Figure 2

A) Evolution of disease activity estimated by DAS28 during the follow-up period in a population of patients with Early Arthritis (EA), and in accordance with the presence of different biomarkers. Left panel: patients with high (grey boxes; n = 50) or low (white boxes; n = 121) sIL-15. Middle panel: patients with positive (grey boxes; n = 75) or negative (white boxes; n = 96) rheumatoid factor reactivity. Right panel: patients with positive (grey boxes; n = 68) or negative (white boxes; n = 103) anti-cyclic citrullinated peptides antibodies. B) Evolution of disease activity estimated by the DAS28 during the follow-up in patients with early Rheumatoid Arthritis (RA; n = 121) or Undifferentiated Arthritis (UA; n = 50) depending on the presence of high (grey boxes) or low (white boxes) IL-15 serum levels. Data are presented as the interquartile range (p75 upper edge of the box, p25 lower edge, p50 midline in the box), as well as the p95 (upper line from the box) and p5. Dots represent the outliers. X-axis shows follow-up visits. Visit 1: baseline; visit 2: six months; visit 3: twelve months; visit 4: twenty four months.