Figure 4. Patterns of DMARD use in a population of early arthritis patients.

Left column: Proportion of patients treated with no DMARD (None; n = 17), DMARDs in monotherapy (Mono; n = 75) or in combined therapy (CT; n = 79) in function of the presence (grey columns) or absence (white columns) of high serum IL-15 (A panel), anti-cyclic citrullinated peptide antibodies (ACPA; B panel) or rheumatoid factor (RF; C panel). Statistical significance was established through Fisher's test. Right column: Proportion of patients treated with methotrexate (MTX; n = 133), leflunomide (LEF; n = 57) or tumor necrosis factor blockers (aTNF; n = 10) in function of the presence (grey columns) or absence (white columns) of high serum IL-15 (D panel), anti-cyclic citrullinated peptide antibodies (ACPA; E panel) or rheumatoid factor (RF; F panel). Statistical significance was established through χ² test, except in the case of aTNF use that was analysed through Fisher's test.