Figure 6. Refining the chromosome 11 critical region bestowing the LT-Induced ERP.
A, Body temperature recordings of backcross progeny (n = 139) as well as B6.CAST.11M (n = 21), B6Nrlp1b (129S1) (n = 5) and B6 control mice (n = 5) following i.p. injection of 15 µg PA+7.5 µg LF. Mice were monitored as previously described. B, Backcross progeny genotypes at microsatellite markers on chromosome 11 were determined by PCR as described in Methods. Lowest body temperature for each animal following LT challenge was determined as described above.