Natural history data on hunter–gatherers and nonhuman primates corroborate the hypotheses that our complex relationships with snakes reflect 80 myr of shared history. (A) Reticulated python, 6.9 m in total length, shot for meat by a Philippine Agta hunter–gatherer in 1970 at a time when 26% of Agta men had survived predatory attacks by pythons (photo by J. Headland). (B) Southern African python, 3.04 m in total length, after killing and before ingesting a vervet monkey, exemplary of snake predation on 26 species of nonhuman primates (photo by B. Maritz).