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Loss of IKKε impacts IFN-I– and IFN-II–mediated transcription. qPCR from RNA derived from Ikbke+/+ and Ikbke−/− MEFs stimulated with IFNβ (A) or IFNγ (B) at the time points indicated. Genes analyzed include Ifit2, Mda5, Viperin, Stat1, Irf1, Irf8, and Icam1. All samples were normalized to Actin and standardized to unstimulated wild-type cells. Error bars represent SDs from triplicate measurements. Experiments were independently repeated at least three times.
