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. 2011 Dec 29;7(12):e1002438. doi: 10.1371/journal.pgen.1002438

Table 1. Overview of the modifiers that suppress Q35 and Q37 (Class A) aggregation in C. elegans BWM cells.

Process(# Genes) Molecular Function (# Genes) Gene
Cell Cycle DNA Synthesis and Replication (8) Cell Cycle (1) cdk-1
DNA recombination (2) fbxb-11; fbxb-17
Meiosis (1) F46F11.9
Replication (4) mcm-2; rnr-2; rpa-1; ruvb-1
Cell structure and Protein transport (6) Cellular matrix, cuticle (4) ppn-1; col-61; col-69; viln-1
Vesicle trafficking (2) klp-15; nex-1
Energy and Metabolism (17) Metabolism (9) C50D2.2; R03D7.1; C47F8.4; C54C8.5; D2030.1; elo-2; W06H3.3; F43G9.1; T22B11.5
Electron transport chain (5) C34B2.8; F59C6.5; ucr-2.3; cyp-13B2; cyp-33D1
Ion transport (2) B0281.5; catp-4
Mitochondrial function (1) F43E2.7
Protein Folding and transport (7) Chaperone (6) F08H9.3; cyn-11; cyn-12; C30C11.4; dnj-22; phb-2
Protein glycosylation (1) tag-335
Protein Synthesis (10) Mitochondrial ribosome (3) C26E6.6; F33D4.5; mrpl-41
Ribosomal protein (3) rpl-2; rpl-35; rps-21
Translation (4) krs-1; F17C11.9; H19N07.1; R05D11.4
RNA Synthesis and Processing (13) Nucleosome binding (2) hmg-3; hmg-4
Ribosome biogenesis (1) C15H11.9
RNA processing, splicing (5) F13H8.2; fib-1; let-716; ZK430.7; Y110A7A.8
Transcription (5) C55A6.9; K03F8.1; fkh-6; gei-11; let-607
Signaling (10) Receptor protein (6) dao-5; xpo-1; sri-57; sri-78; srz-53; T11F1.6
Transduction (4) clec-19; pdl-1; rgl-1; W03B1.9
Unknown (17) Unknown (17) C23G10.10; C45G3.4; F14B8.2; F26E4.2; F47F2.3; K02E7.11; ptr-19; R05D7.2; ril-1; smu-1; T04D3.5; vab-19; F53F10.1; W03B1.5; Y51H7BR.3; fbxa-76; F54C4.3
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