Table 2. Core modulators of protein homeostasis in C. elegans BWM cells.
| Gene/Cosmid | Class | Molecular function | Human ortholog | Expression | TS | Direct Interactors (STRING 9.0) |
| ucr-2.3 | EM | Ubiquinol cytochrome c reductase, complex III ETC | UQCRC2, Cytochrome b-c1 complex III | Ubiquitous, mitochondrial | 3/4 | ETC complex III subunits: cyc-1, isp-1, ucr-2.2, T27E9.2, F45H10.2, T02H6.11, R07E4.3. F57B10.14 (unknown). |
| F43G9.1 | EM | Isocitrate dehydrogenase α-subunit, TCA cycle | IDH3A, Isocitrate dehydrogenase, α-subunit | Ubiquitous, mitochondrial | 2/4 | Aconitase (aco-1, aco-2), ATP synthase (atp-2), Isocitrate dehydrogenase subunits (C37E2.1, idh-1, idh-2, C30F12.7, F35G12.2) OGDH subunits (T22B11.5, ZK836.2) |
| T22B11.5 | EM | 2-oxoglutarate dehydrogenase, E1 subunit, TCA cycle | OGDHL, 2-oxoglutarate dehydrogenase E1 | Ubiquitous, mitochondrial | 4/4 | OGDH subunit (W02F12.5, ZK836.2), Isocitrate dehydrogenase subunits(idh-1, idh-2, C37E2.1,C30F12.7, F43G9.1), LLC1.3, glutaryl-CoA-dehydrogenase (F54D5.7), Malonyl-CoA decarboxylase (F35G12.1) |
| ZK430.7 | RSP | Sof1-like rRNA processing protein | WDSOF1, WD repeat and SOF domain-containing protein 1 | Muscle enriched, nucleus | 4/4 | rRNA processing (fib-1, C05C8.2), ribosome (C48B6.2, nep-1, F13H8.2), acyltransferase (F55A12.8), tryptophan protein 2 (F55F8.3), Bystin (byn-1), nucleolar protein (nol-10) |
| Y110A7A.8 | RSP | Putative mRNA splicing factor PRP31 | PRPF31, U4/U6-SNRP | Oogenesis enriched | 4/4 | RNA processing and splicing: prp-8, M28.5, Y59A8B.6, prp-4, rpl-3, ism-6. M03C11.4 (unknown) |
| gei-11 | RSP | GEX-interacting protein 11 MYB-family | SNAPC4, MYBL2, MYB, MYBL1 | Nucleus | 4/4 | Acetylcholine receptor subunit (unc-29), tissue morphogenesis (gex-3) |
| let-607 | RSP | CREB-ATF transcription factor | CREB3L3/L4, CREBH transcription factor | BWM, neurons, vulva, pharynx, spermatheca, ER, nucleus | 4/4 | - |
| R05D11.4 | PS | ATP-dependent RNA helicase, translation | DDX52, ATP-dependent RNA helicase | Intestine, muscle, cytoplasm | 1/4 | - |
| C45G3.4 | U | Unknown | Unknown | - | 1/4 | - |
Key: EM (energy and metabolism); RSP (RNA synthesis and processing); PS (protein synthesis); U (unknown); TS (temperature sensitive mutant proteins showing suppression of phenotype/total tested).