Figure 9. Experimental infection of Swiss new born and IFNAR^(−/−) adult mice with wt and ΔNS4 viruses.

Survival plots of either 3-days old mice inoculated intracerebrally or adult sv129 IFNAR^(−/−) inoculated intraperitoneally with the following viruses: BTV-8 (dark red, square), BTV8-ΔNS4 (red, triangle), BTV-1 (blue, square) and BTV1-ΔNS4 (light blue, triangle) viruses. Mock-infected mice are shown in gray, circle. Mice were killed at two weeks post-inoculation, or earlier, if showing advanced clinical signs of systemic disease.