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. Author manuscript; available in PMC: 2011 Dec 29.
Published in final edited form as: Immunol Rev. 2009 Mar;228(1):23–40. doi: 10.1111/j.1600-065X.2008.00758.x

TABLE 1.

Dual role of Lyn in the modulation of myeloid-cell signaling responses and functions

RECEPTOR Ligand Cell type Function
 Negative role
Type I cytokine receptors GM-CSF, G-CSF,IL-3, IL-6 MP, Mφ,DC,MC proliferation, survival
Immunoglobuline superfamily receptors M-CSF, SCF MP, Mφ, MC proliferation
FcεRI IgE MC proliferation, degranulation, cytokine production
Integrin extracellular matrix proteins, counter receptors Mφ,PMN,MP adhesion, activation, survival
 Positive role
Type I cytokine receptors
7 transmembrane α-helical receptors		 IL-5, G-CSF, GM-CSF
chemokines		 PMN, E
PMN, Mφ, MP, MC		 survival, proliferation
activation, migration

The table list specific receptors, ligands, cell types and functions that are either positively or negatively regulated by Lyn. MP, myeloid precursors; Mφ, macrophages; DC, dendritic cells; MC, mast cells; PMN, neutrophils; E, eosinophils.