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. Author manuscript; available in PMC: 2012 Dec 18.

Published in final edited form as: Toxicology. 2011 Oct 14;290(2-3):272–278. doi: 10.1016/j.tox.2011.10.006

Involvement of oxidative stress in BMP mediated DNA damage. (A) Oxidative base modifications in UROtsa cells following 1h of BMP (25μM), KBrO₃(2mM) and H₂O₂(100μM) exposure measured by hOGG1 modified comet assay. Gray Bars represent the net increase in T_%DNA after incubation with hOGG1. (B) Protective effects of NAC (2mM) on BMP (10–100μM) induced DNA strand breaks in UROtsa cells. Data are shown as mean ± SEM, N=3. *P<0.05 versus vehicle control, ^#P<0.05 versus cells without NAC pre-treatment.

Involvement of oxidative stress in BMP mediated DNA damage. (A) Oxidative base modifications in UROtsa cells following 1h of BMP (25μM), KBrO₃(2mM) and H₂O₂(100μM) exposure measured by hOGG1 modified comet assay. Gray Bars represent the net increase in T_%DNA after incubation with hOGG1. (B) Protective effects of NAC (2mM) on BMP (10–100μM) induced DNA strand breaks in UROtsa cells. Data are shown as mean ± SEM, N=3. *P<0.05 versus vehicle control, ^#P<0.05 versus cells without NAC pre-treatment.