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The effect of AMPK is dependent on the AMP concentration. The bar graph depicts KATP channel current recorded at −60 mV in the presence of 300 µM ATP and 1U/ml AMPK. In control, no AMP was present. Increasing the AMP concentration dose-dependently increased KATP channel activity. The right-most bar represents recordings made with 300 µM AMP and heat-inactivated AMPK. In all cases, NPo was normalized to recordings made in the presence of 300 µM ATP and absence of AMP.
