Fig. 2.

Schematic of the potential activites of find-me signals. Find-me signals may promote phagocytic activity of neighboring cells, perhaps by upregulating phagocytic machinery (receptors and intracellular signaling molecules). Find-me signals may also act on vascular endothelial cells to induce the upregulation of molecules that promote monocyte extravasation (such as adhesion molecules and chemokines). Find-me signal chemotactic gradient would then mediate migration of resident or recruited phagocytes within the interstitium.