. Author manuscript; available in PMC: 2012 Aug 1.

Published in final edited form as: Pharmacogenomics J. 2010 Apr 13;11(4):274–286. doi: 10.1038/tpj.2010.28

Table 5.

CYP3A4 intron 6 SNP genotype and stable statin dose

Statins	N	Dose ratio (T carrier/non-T carrier)	95% confidence interval	P-value
CYP3A4 substrates	235	0.27	0.19–0.66	0.019^*
Atorvastatin	142	0.22	0.14–0.54	0.024^*
Simvastatin	84	0.6	0.37–0.97	0.042^*

Abbreviations: CYP, cytochrome p450; hnRNA, heteronuclear RNA; SNP, single nucleotide polymorphism.

P<0.05.