Skip to main content
. Author manuscript; available in PMC: 2012 Jul 15.
Published in final edited form as: Bioorg Med Chem Lett. 2011 Jun 2;21(14):4164–4169. doi: 10.1016/j.bmcl.2011.05.098

Table 1.

SAR on the pyrimidine ring and respective IC50 values.

graphic file with name nihms301425u1.jpg HDAC IC50 (μM)a
Compound R 1 2 3 4 5 6 7 8 9
7 graphic file with name nihms301425t1.jpg 16.4 (±1.08) 18.9 (±1.10) 15.2 (±1.05) 32.5 (±1.07) 27.9 (±1.05) 11.2 (±1.09) 24.4 (±1.07) 23.9 (±1.07) 74.1 (±1.10)
8 graphic file with name nihms301425t2.jpg >100 >100 >100 >100 >100 >100 >100 >100 >100
9 graphic file with name nihms301425t3.jpg >100 >100 >100 >100 >100 >100 >100 >100 >100
10 graphic file with name nihms301425t4.jpg >100 >100 >100 >100 >100 >100 >100 >100 >100
11 graphic file with name nihms301425t5.jpg >100 >100 >100 >100 >100 >100 >100 >100 >100
12 graphic file with name nihms301425t6.jpg >100 >100 >100 54.2 16.7 88.0 31.9 >100 11.7
13 graphic file with name nihms301425t7.jpg >100 >100 >100 >100 >100 >100 >100 >100 >100
a

Values are means of >2 experiments