Table 1.
HDAC IC50 (μM)a | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|
Compound | R | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 |
7 | 16.4 (±1.08) | 18.9 (±1.10) | 15.2 (±1.05) | 32.5 (±1.07) | 27.9 (±1.05) | 11.2 (±1.09) | 24.4 (±1.07) | 23.9 (±1.07) | 74.1 (±1.10) | |
| ||||||||||
8 | >100 | >100 | >100 | >100 | >100 | >100 | >100 | >100 | >100 | |
9 | >100 | >100 | >100 | >100 | >100 | >100 | >100 | >100 | >100 | |
10 | >100 | >100 | >100 | >100 | >100 | >100 | >100 | >100 | >100 | |
11 | >100 | >100 | >100 | >100 | >100 | >100 | >100 | >100 | >100 | |
12 | >100 | >100 | >100 | 54.2 | 16.7 | 88.0 | 31.9 | >100 | 11.7 | |
13 | >100 | >100 | >100 | >100 | >100 | >100 | >100 | >100 | >100 |
Values are means of >2 experiments