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. Author manuscript; available in PMC: 2012 Jul 15.
Published in final edited form as: Bioorg Med Chem Lett. 2011 Jun 2;21(14):4164–4169. doi: 10.1016/j.bmcl.2011.05.098

Table 2.

SAR on the phenyl moiety and respective IC50 values.

graphic file with name nihms301425u2.jpg HDAC IC50 (μM)a
Compound R 1 2 3 4 5 6 7 8 9
14 graphic file with name nihms301425t8.jpg >100 >100 >100 >100 >100 >100 >100 >100 >100
15 graphic file with name nihms301425t9.jpg >100 >100 >100 >100 >100 >100 >100 >100 >100
16 X = H >100 >100 >100 >100 >100 13.7 >100 >100 >100
17 graphic file with name nihms301425t10.jpg >100 >100 >100 >100 >100 >100 >100 >100 >100
18 graphic file with name nihms301425t11.jpg >100 >100 >100 >100 >100 10.8 >100 >100 >100
19 X = OCH3 >100 >100 >100 >100 >100 60.9 >100 >100 >100
20 X = tBu >100 >100 >100 >100 94.3 >100 >100 >100 >100
21 X = Cl 82.3 67.0 86.4 >100 >100 12.9 >100 >100 >100
22 X = OH >100 >100 >100 >100 >100 40.1 >100 >100 >100
23 graphic file with name nihms301425t12.jpg >100 >100 >100 >100 >100 16.7 >100 >100 >100
24 graphic file with name nihms301425t13.jpg >100 >100 >100 >100 >100 >100 >100 >100 >100
25 graphic file with name nihms301425t14.jpg >100 >100 >100 >100 >100 32.6 >100 >100 >100
26 graphic file with name nihms301425t15.jpg >100 >100 >100 >100 >100 24.8 >100 >100 >100
27 graphic file with name nihms301425t16.jpg >100 >100 >100 >100 >100 >100 >100 >100 >100
28 graphic file with name nihms301425t17.jpg >100 >100 >100 >100 >100 >100 >100 >100 >100
29 graphic file with name nihms301425t18.jpg >100 >100 >100 >100 >100 >100 >100 >100 >100
30 graphic file with name nihms301425t19.jpg 77.2 69.3 40.0 >100 48.6 7.2 >100 >100 >100
31 n = 3 >100 >100 >100 >100 >100 >100 >100 >100 >100
32 n = 1 >100 >100 >100 >100 >100 >100 >100 >100 >100
33 n = 5 >100 >100 >100 >100 >100 >100 >100 >100 >100
a

Values are means of >2 experiments