Table 5.

Adjusted Odds of Selected Outcomes After the Diagnosis of VTE According to Study Year

	% Developing Event	Crude Hazards Ratio	Multivariable Adjusted Hazards Ratio*	Multivariable Adjusted Hazards Ratio†
Recurrent VTE
1999	17.5	1.0	1.0	1.0
2001	17.2	0.97(0.71,1.32)	0.94(0.69,1.28)	0.99(0.72,1.34)
2003	15.3	0.79(0.57,1.09)	0.76(0.54,1.05)	0.75(0.54,1.04)
New or recurrent PE
1999	3.8	1.0	1.0	1.0
2001	6.0	1.60(0.89,2.88)	1.62(0.89,2.92)	1.63(0.90,2.95)
2003	5.0	1.01(0.53,1.95)	0.98(0.50,1.90)	0.98(0.50,1.90)
Major Bleeding
1999	12.4	1.0	1.0	1.0
2001	12.7	1.05(0.73,1.49)	1.03(0.72,1.48)	1.04(0.73,1.49)
2003	12.2	0.97(0.68,1.40)	0.98(0.68,1.42)	0.98(0.68,1.41)
Mortality
1999	43.3	1.0	1.0	1.0
2001	42.8	1.00(0.83,1.21)	1.03(0.85,1.25)	1.04(0.86,1.26)
2003	37.7	0.83(0.69,1.01)	0.90(0.74,1.10)	0.90(0.74,1.10)

^*Adjusted for age, sex, VTE risk factors (recent (< 3 months prior to VTE diagnosis) hospitalization, surgery, serious infection, central venous catheter, ICU discharge, hormonal therapy, fracture, congestive heart failure, cardiac procedures), and active cancer (treated, palliative, or metastatic).

^†Adjusted for above variables plus VTE type (e.g. DVT vs. PE) and DVT location (upper extremity vs. lower extremity, isolated calf vein versus more proximal DVT).