Table 5.
Regression Models of Genotypesa Predicting Log-transformedb Blood Manganese (μg/L)
| Crude | Adjusted for Hemoglobin | Fully Adjustedc | |||||||
|---|---|---|---|---|---|---|---|---|---|
| Genotype | N | Beta | (95% CI) | N | Beta | (95% CI) | N | Beta | (95% CI) |
| HFE C282Y | 330 | -0.23 | (-0.52 to 0.05) | 327 | -0.23 | (-0.51 to 0.06) | 324 | -0.22 | (-0.53 to 0.08) |
| HFE H63D | 328 | -0.09 | (-0.20 to 0.03) | 325 | -0.08 | (-0.20 to 0.03) | 322 | -0.08 | (-0.20 to 0.03) |
| HFEd | 331 | -0.12 | (-0.23 to -0.01) | 328 | -0.12 | (-0.23 to -0.01) | 325 | -0.11 | (-0.23 to -0.003) |
| TF P570S | 329 | 0.01 | (-0.10 to 0.12) | 326 | 0.02 | (-0.09 to 0.13) | 323 | 0.02 | (-0.10 to 0.13) |
| ALAD K59N | 330 | 0.02 | (-0.16 to 0.20) | 327 | -0.01 | (-0.20 to 0.18) | 324 | -0.02 | (-0.20 to 0.17) |
a All models compare blood manganese levels among women with any variant allele to levels among women with no variant allele
b Blood manganese concentrations are transformed to their natural logarithms; beta coefficients therefore represent percent change in manganese for carriers of variant alleles compared to women with no variant allele
c Models adjusted for hemoglobin at 1-month postpartum and gestational age
d C282Y or H63D