Table 2.

Trials without significant difference between antibiotic monotherapy and combination therapy for CAP

Author	Year	Cohort	Outcome	Study design
Burgess and Lewiss [30]	2000	Hospitalized CAP without identified microorganism	Nonstatistical differences third-generation cephalosporin ± macrolide	Bicenter, retrospective
Dwyer et al. [31]	2006	Bacteremic pneumococcal CAP	No significant difference in case fatality if initial β-lactam + macrolide	Multicenter, retrospective
Harbarth et al. [32]	2005	Pneumococcal sepsis	Lack of effect of combo therapy	Multicenter, retrospective
Leroy et al. [33]	2005	CAP without vasopressors	Levofloxacin vs. cefotaxime + ofloxacin	Multicenter, retrospective