Table 1.

Candidates genes for FTO-interaction studies based on results from queries in Funcoup, Coxpresdb and IntAct (see Figure 1).

Candidate genes	Name	Function
PFN2	Profilin 2	Regulates actin polymerization in response to extracellular signals
NRTK2	Neurotrophic tyrosine kinase receptor type 2	Receptor for BDNF
BDNF	Brain derived neurotrophic factor	involved in neuronal plasticity & differentiation
PRKACB	cAMP dependent protein kinase catalytic subunit beta	Ser/Thr protein kinase, catalytic subunit of AMP-activated protein kinase (AMPK)
VAMP2	Vesicle-associated membrane protein 2. alt. Synaptobrevin-2	Involved in the targeting and/or fusion of transport vesicles to their target membrane.
STAT3	Signal transducer and activator of transcription 3	Transcription factor involved in cell growth and apoptosis. Responds to leptin signalling.
NLN	Neurolysin	Hydrolyzes oligopeptides such as neurotensin, bradykinin and dynorphin A
BTBD12	SLX4 structure-specific endonuclease subunit homolog	DNA-repair, endonuclease activity.
ZBTB20	Zinc finger and BTB domain-containing protein 20	May be a transcription factor that may be involved in hematopoiesis, oncogenesis, and immune responses
ATF7IP	Activating transcription factor 7-interacting protein	A regulator of telomerase reverse transcriptase (TERT) expression

STAT3 was included in our analysis due to previous publications suggesting a link between this gene and FTO [36].