TABLE 1:
Cell cycle kinetics in human tumors and tissues estimated by pulse labeling with 3H-thymidine and by doubling time.
| Cell type | S phase cells (%) | Doubling time (d) |
|---|---|---|
| Breast cancer (primary) | 2–5 | ∼40–300 |
| Beast cancer (metastasis) | 3–14 (0–40 in individuals) | ∼30–90 |
| Bone marrow myeloid progenitor cells | ∼40 | ∼3 |
| Gut crypts | 10–16 | |
| Tissue culture cell line | ∼40 | ∼1 |
The ranges refer to median values reported in different studies. The range inside brackets refers to individual patient values in one large study. Data from Skipper and Perry (1970), Skipper (1971), Meyer et al. (1984), Lord (1992), Amadori et al. (1997), and Komlodi-Pasztor et al. (2011).