FIGURE 1:

Amino acid sequence alignment of T. thermophila Rnt2 family members. Absolutely conserved residues are indicated with black background, and residues conserved in five to eight sequences are indicated with gray background. The two active-site motifs CAS I and CAS II are indicated below the sequence alignment, and the two catalytic histidines are marked with an asterisk above. The conserved cysteines involved in disulfide bridges are also indicated above the sequence alignment and are numbered according to previous annotation (Irie, 1999). The N-terminal signal peptides predicted by SignalP are underlined.