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. 2012 Jan 1;23(1):99–110. doi: 10.1091/mbc.E11-06-0497

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© 2012 Smith et al. This article is distributed by The American Society for Cell Biology under license from the author(s). Two months after publication it is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0).

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FIGURE 4: — ROCK1 physically associates with the cadherin complex in a p120-dependent manner. (A) Coimmunoprecipitation of ROCK1 with wild-type E-cadherin in DSP–cross-linked A431D cells. Western blot analysis of ROCK1, p120, and E-cadherin in whole-cell lysates containing 10% of input (lanes 1, 5, and 9) or immunoprecipitations generated using p120 (lanes 2, 6, and 10), E-cadherin (lanes 3, 7, and 11), or control IgG (lanes 4, 8, and 12) mAbs. (B) A model depicting p120-dependent association of ROCK1 with the cadherin complex, as detected by immunoprecipitation in (A). The extracellular domain of E-cadherin has been truncated in this schematic.